A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/180
A61K 38/14 (2006.01) A23K 1/17 (2006.01)
Patent
CA 1158980
Case 4-12545/+ Antibiotic preparations with increased efficacy, production thereof, and method of intensifying the action of antibiotics Abstract of the Disclosure The present invention relates to a method of intensifying the action of antibiotics, to antibiotic preparations having increased efficacy, and to the production thereof. The method comprises the administration of an antibiotic selected from the group consisting of the .beta.-lactam antibiotics, aminoglycosides, tetracyclines, macrolides, lincomycins, polyene antibiotics, polypeptide antibiotics, anthracyclines, chloro- or thiamphenicols, cycloserins, fusidic acids or rifamycins, together with a muramylpeptide of the formula (I) Image wherein R1 is lower alkyl, phenyl, lower alkoxy or phenyl-lower alkoxy, each of which is substituted or unsubstituted, R2 is hydrogen or acyl, R3 is hydrogen or lower alkyl, R4 is hydrogen or lower alkyl, and R5 is hydrogen or lower alkyl or phenyl, each of which is substituted or unsubstituted, or R4 and R5 together are lower alkylene, and each of - 2 - R6 and R7 is free or etherified hydroxyl or substituted or unsubstituted amino, and/or one or more salts of a compound of the formula I containing at least one salt-forming group.
361259
Dietrich Felix M.
Dukor Peter
Sackmann Werner
Zak Otokar
Fetherstonhaugh & Co.
Novartis Ag
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