C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/54 (2006.01) A61K 31/505 (2006.01) A61P 31/04 (2006.01) C07D 239/545 (2006.01) C07D 473/18 (2006.01)
Patent
CA 2375066
The invention relates to prodrugs of N-substituted derivatives of 6- aminouracils, 6-aminoisocytosines, guanines, and 2-aminoadenines. The N-linked substituents include an ester group that is cleaved upon administration into a subject to yield a substituent having a terminal hydroxyl group. Pharmaceutical compositions including these compounds, and methods for treating Gram-positive bacterial infections using these compounds, are also disclosed.
La présente invention concerne des promédicaments de dérivés N-substitués de 6-aminouracils, 6-aminoisocytosines, guanines, et 2-aminoadenines. Les substituants N-liés contiennent un groupe ester qui est coupé suite à son administration à un sujet pour obtenir un substituant à groupe hydroxyle terminal. En outre, cette invention concerne des compositions pharmaceutiques contenant ces composés ainsi que des méthodes destinées à traiter les infections bactériennes à Gram positif au moyen de ces composés.
Brown Neal C.
Wright George E.
Zhi Chengxin
Smart & Biggar
University Of Massachusetts
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