C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) C12N 15/09 (2006.01) C12N 15/52 (2006.01) C12P 19/00 (2006.01) C12P 19/26 (2006.01)
Patent
CA 2322241
Methods are provided for increasing and altering the timing of antibiotic production in Streptomyces species, particularly S. coelicolor and S. lividans, by functionally deleting the S. coelicolor scbA and scbR genes, respectively, or their homologues. Also provided are strains having such mutations, and methods of producing antibiotics using such strains. Also provided are methods for identifying strains in which functional deletion of the scbA and/or scbR genes or their homologues leads to the above effects.
Bibb Mervyn
Takano Eriko
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Plant Bioscience Limited
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