Antibiotic quinolones and derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 215/20 (2006.01) A61K 31/435 (2006.01) A61K 31/4375 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/495 (2006.01) C07D 215/233 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2206914

A compound of the formula I Image I (wherein R1 is H, alkyl or the like; R2 is alkyl, alkenyl, alkynyl, phenyl, heteroaryl or the like; R3 is alkyl, phenyl, benzyl or the like; R4, R5, R6 and R7 are H or substituent; and X, Y and Z are C or N) is an inhibitor of H. pylori and therefore useful in the treatment and prevention of peptic ulcers, gastritis, dyspepsia, and gastric cancer.

Composé de formule I Image I (où R1 est H, un alkyle ou groupe analogue; R2 est un groupe alkyle, alcényle, alcynyle, phényle, hétéroaryle ou un groupe analogue; R3 est un groupe alkyle, phényle, benzyle ou un groupe analogue; R4, R5, R6 et R7 sont H ou un substituant; X, Y et Z sont C ou N); le composé est un inhibiteur de H. pylori et, par conséquent, utile pour le traitement et la prévention des ulcèrex gastro-duodénaux, de la dyspepsie et des cancers gastriques.

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