Antibiotic substances

Details Antibiotic substances Antibiotic substances

C - Chemistry, Metallurgy

12

P

195/96, 260/1.39

C12P 19/44 (2006.01) A61K 35/66 (2006.01) C07G 11/00 (2006.01)

Patent

CA 1063051

ABSTRACT This invention relates to a process for producing an antibiotic activity consisting of three separable fractions named metabolite A, Gardimycin and metabolite C, which comprises cultivating a strain selected from Actinoplanes garbadinensis ATCC 31049, Actinoplanes liguriae ATCC 31048 and the equivalents thereof, under aerobic conditions, in an aqueous nutrient medium containing an assimilable source of carbon, an assimilable source of nitrogen and inorganic salts, until a substantial antibiotic activity is present in the medium, recovering said antibiotic activity therefrom, and separating it into the three fractions. It also relates to the strains used in this process namely Actinoplanes garbadinensis and Actinoplanes liguriae. Furthermore the invention relates to the antibiotic substances which are produced by the process of claim 1 i.e. Gardimycin together with its salts. These products are active against a wide range of microorganisms particularly against clinically isolated streptocaucus strains.

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