C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) C07D 487/02 (2006.01) C07D 487/04 (2006.01) C07D 491/02 (2006.01) C07D 491/04 (2006.01) C07D 495/02 (2006.01)
Patent
CA 2707442
Disclosed are compounds of Formula (I), pharmaceutical compositions comprising Formula (I) and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and prevention of diseases caused by bacteria, particularly bacteria dependent on PPAT, for example, species such Escherichia coli, Helicobacter pylori, Staphyloccocus aureus, and the like.
La présente invention concerne des composés de Formule I, des compositions pharmaceutiques comprenant la Formule I et des procédés de traitement des infections bactériennes. Les composés décrits sont des inhibiteurs de la PPAT (phosphopantéthéine adényl transférase) et sont utiles dans le traitement et la prévention de maladies causées par des bactéries, en particulier des bactéries dépendant de la PPAT, par exemple, des espèces telles quEscherichia coli, Helicobacter pylori, Staphyloccocus aureus et analogue.
Biota Scientific Management Pty Ltd
Gowling Lafleur Henderson Llp
LandOfFree
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