Antibiotically active compounds and their fermentative...

Details Antibiotically active compounds and their fermentative... Antibiotically active compounds and their fermentative...

C - Chemistry, Metallurgy

12

P

235/82, 195/89

C12P 17/18 (2006.01) C07D 498/08 (2006.01) C07D 498/10 (2006.01) C07D 498/18 (2006.01)

Patent

CA 1146885

Abstract New antibiotically active compounds having the basic structure of rifamycin S, namely 3-hydroxyrifamycin S (formula A: X = Image : R1 = OH: R2 = H), 3, 31-dihydroxy- rifamycin S (formula A: X = Image : R1 = R2 = OH) and 1- desoxy-1-oxarifamycin S (formula A: X = -O-: R1 = R2 = H) Image (A) are formed by sultivating, under aerobic conditions, a strain of Nosardia mediterranei which is derived from Streptomyces ??diterranei ATCC 13 685 as the parent strain and is characterised by the ability to produce at least one of the mentioned compounds. The recombinant strain Nocardia meditarranei DSM 1415 has proved suitable. The mentioned ?ifamycin S a????gues have analogous anti- biotic properties to this but have a wider range of action, especially against gram-negative bacyeria.

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