Antibiotics

Details Antibiotics Antibiotics

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/26 (2006.01)

Patent

CA 1048016

ABSTRACT OF THE DISCLOSURE Cephalosporin antibiotics in which the 7.beta.-acylamido group has the structure Image where R1 is a furyl, thienyl or phenyl group and R2 is a C1-C4 alkyl, C3 -C7 cycloalkyl or phenylgroup except that R2 may not represent a methyl group when R1 represents a furyl group, and in which the 3-position substituent is a carbamoyloxymethyl group possess a particularly valuable combination of properties, exhibiting high anti- bacterial activity against a broad range of gram positive and gram negative organisms, particularly high stability to .beta.-lactamases produced by various organisms, and stability in vivo. Such compounds include the non- toxic salts, biologically acceptable esters, 1-oxides and solvates of the parent 4-carboxylic acids. The compounds are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer. The above compounds may be prepared by (a) acylation of the corresponding 7-amino compound or (b) carbamoylation of the corresponding 3-hydroxymethyl compound. - 1 -

293802

Affiliated with

Also associated with

Rating

Antibiotics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibiotics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibiotics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-582599