Antibiotics neothramycin a and b from streptomyces

Details Antibiotics neothramycin a and b from streptomyces Antibiotics neothramycin a and b from streptomyces

C - Chemistry, Metallurgy

12

P

195/104, 260/240

C12P 19/44 (2006.01) C07D 243/14 (2006.01) C07G 11/00 (2006.01)

Patent

CA 1056747

Abstract of the Disclosure There are disclosed two new antibiotics neothramycin A having the formula: Image and neothramycin B having the formula: Image which are potent inhibitors of the growth of leukemia cells, e. g. Leukemia L-1210 cells in mice. They are produced by controlled fermentation of the strain of Streptomyces (identified as A.T.C.C. 31123) under submerged con- ditions in a nutrient medium containing a carbon source and a nitrogenous nutrient until a substantial amount of antibiotics is produced in the nutrient medium.

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