A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2566305
Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are nucleic acids encoding the immunoglobulin chains, vectors and host cells having the nucleic acids, and methods of inducing death of an activated T cell and of modulating a T cell- mediated immune response in a subject.
Des chaînes d~immunoglobine ou des anticorps ayant une complémentarité de chaîne légère ou lourde déterminant les régions d~anticorps qui se lient à la P-sélectine glycoprotéine ligand-1. L~invention concerne également des acides nucléiques qui codent les chaînes d~immunoglobine, des vecteurs et des cellules hôtes ayant ces acides nucléiques, ainsi que des méthodes permettant de provoquer la mort d~un lymphocyte T activé et de moduler une réponse immune induite par un lymphocyte T chez un sujet.
Chang Chung Nan
Chen Pei-Jiun
Huang Chiu-Chen
Lin Rong-Hwa
Abgenomics Cooeperatief U.a.
Abgenomics Corporation
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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