Antibodies against a cancer-associated epitope of variant...

Details Antibodies against a cancer-associated epitope of variant... Antibodies against a cancer-associated epitope of variant...

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/21 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) G01N 33/574 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2703140

The present application provides the amino acid and nucleic acid sequences of heavy and light chain complementarity determining regions of a cancer specific antibody directed to an epitope of variant Heterogeneous Ribonucleoprotein G (HnRNPG). In addition, the application provides cancer specific antibodies and immunoconjugates comprising the cancer specific antibody attached to a toxin or label, and methods of uses thereof. The application also relates to diagnostic methods and kits using the cancer specific antibodies disclosed herein. Further, the application provides novel cancer-associated epitopes and antigens of variant HnRNPG, and uses thereof.

La présente invention porte sur les séquences d'acides aminés et d'acides nucléiques de régions déterminant la complémentarité de chaînes lourde et légère d'un anticorps spécifique du cancer dirigé contre un épitope de ribonucléoprotéine G hétérogène variante (HnRNPG). De plus, l'invention porte sur des anticorps spécifiques du cancer et sur des immunoconjugués comprenant l'anticorps spécifique du cancer attaché à une toxine ou à un marqueur, et sur des procédés d'utilisation de ceux-ci. La demande porte également sur des procédés de diagnostic et des coffrets utilisant les anticorps spécifiques du cancer décrits dans celle-ci. De plus, la demande porte sur de nouveaux épitopes et antigènes de HnRNPG variante associés au cancer et sur leurs utilisations.

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