Antibodies against and compositions containing new...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/13 (2006.01) A61K 39/35 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07C 211/26 (2006.01) C07C 229/36 (2006.01) C07K 16/44 (2006.01) C12N 5/12 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2474259

Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo to amphetamines are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. A therapeutic composition containing the hapten-carrier conjugate is useful in the treatment of addiction to amphetamines. Passive immunization using antibodies raised against conjugates of the instant invention also is disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs for treatment of amphetamine abuse.

La présente invention concerne des conjugués porteurs d'haptène, permettant d'obtenir des anticorps anti-haptène luttant in vivo contre des amphétamines. La présente invention concerne également des procédés pour préparer ces conjugués porteurs d'haptène et des compositions thérapeutiques. Une composition thérapeutique contenant le conjugué porteur d'haptène est utilisée pour traiter une toxicomanie aux amphétamines. Cette invention a également trait à une immunisation passive obtenue par utilisation d'anticorps luttant contre des conjugués selon la présente invention. La composition thérapeutique selon cette invention est adaptée à une co-thérapie avec d'autres médicaments classiques pour traiter un abus d'amphétamines.

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