Antibodies against and methods for producing vaccines for...

A - Human Necessities – 61 – K

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A61K 39/12 (2006.01) C07K 14/135 (2006.01) C07K 16/08 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2580921

The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody binding to F peptides. The present invention also relates to antibodies that immunospecifically bind to an F peptide of the present invention. The invention further provides methods and protocols for the administration of F peptides and/or antibodies that immunospecifically bind to F peptides for the prevention, neutralization, treatment of RSV infection. Additionally, the methods of the invention may be useful for the treatment, prevention and the amelioration of symptoms associated with RSV infection.

La présente invention se rapporte à de nouveaux peptides F du virus respiratoire syncytial (RSV) ainsi qu'à des compositions contenant ces peptides. La présente invention se rapporte également à des procédés permettant d'évaluer la liaison des anticorps anti-RSV à ces peptides F. La présente invention se rapporte également à des anticorps qui se lient de manière immunospécifique à un peptide F décrit ci-dessus. L'invention se rapporte également à des procédés et à des protocoles pour l'administration de peptides F et/ou d'anticorps qui se lient de manière immunospécifique à des peptides F, aux fins de la prévention, de la neutralisation et du traitement de l'infection par RSV. En outre, les procédés de l'invention peuvent être utiles pour le traitement, la prévention et l'amélioration des symptômes associés à l'infection par le RSV.

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