Antibodies against april as biomarkers for early prognosis...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/24 (2006.01) C07K 7/08 (2006.01) C12N 5/16 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2623530

The invention relates to antibodies directed against APRIL (A Proliferation Inducing TNF Ligand, also known as TALL-2) , in particular the monoclonal antibody Aprily-2, hybridoma cells producing monoclonal antibody Aprily-2, and the use of a combination of an antibody against membrane-anchored APRIL and Aprily-2 in the diagnosis of B cell lymphoma resistance to treatment and the prognosis of clinical development of Diffuse Large B-CeII (DLBCL) lymphoma from high risk patients (> 60 years and International Prognostic Index > 2) . An amino acid sequence GTGGPSQNGEGYP called Stalk, useful in the preparation of antibodies, is described.

L'invention a pour objet des anticorps dirigés contre APRIL (A Proliferation Inducing TNF Ligand, aussi connu sous le nom de TALL-2), en particulier l'anticorps monoclonal Aprily-2, des cellules hybridome qui produisent l'anticorps monoclonal Aprily-2, et l'utilisation d'une combinaison d'un anticorps anti-APRIL et anti-Aprily-2 ancré dans une membrane dans le diagnostic de la résistance au traitement du lymphome à cellules B et le pronostic de l~évolution clinique du lymphome diffus à grandes cellules B (DLBCL) de patients à hauts risques (> 60 ans et index pronostique international > 2) . Une séquence d'acides aminés GTGGPSQNGEGYP appelé Stalk, utile dans la préparation d'anticorps, est décrite.

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