Antibodies against bacterial peptidoglycans, processes for...

Details Antibodies against bacterial peptidoglycans, processes for... Antibodies against bacterial peptidoglycans, processes for...

A - Human Necessities

61

K

167/139, 167/37

A61K 39/40 (2006.01) G01N 33/531 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) G01N 33/58 (2006.01)

Patent

CA 1218299

Abstract Antibodies against bacterial peptidoglycans Antibodies from the class of immunoglobulins G against the peptide sub-unit pentapeptide L-Ala- D-Glu(L-Lys-D-Ala-D-Ala) of peptidoglycans in biological test material and against bacterial cell walls containing these peptidoglycans may be extracted from human plasma and are useful in the investigation of collagen diseases. Such antibodies may possess the ability to bind to (a) pentapeptides of formula I R - A1 - D - Ala (I) (wherein R represents an amino acid component with 1, 2 or 3, preferably 3, amino acid residues selected from Gly, L-Ala, D-Glu and L-Lys; and A1 represents one of the amino acid residues D-Ala, D-Ser, D-Val and D-Leu); or (b) bacterial cell walls or cell wall material which contain pentapeptides of formula I; or (c) Gram-positive bacteria which contain pentapeptides of formula I.

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