Antibodies against carboxic anhydrase ix (ca ix) tumor antigen

A - Human Necessities – 61 – K

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Details

A61K 39/44 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/40 (2006.01)

Patent

CA 2467738

The present invention relates generally to the generation and characterization of anti-CA IX monoclonal antibodies. The invention further relates to the use of such anti-CA IX antibodies in the diagnosis and treatment of disorders associated with increased activity of CA IX, in particular, tumors such as colorectal cancer, renal cell carcinoma (RCC), cervical and other cancers of epithelial origin.

L'invention concerne d'une manière générale la production et la caractérisation d'anticorps monoclonaux anti-CA IX. Elle concerne en outre l'utilisation de ces anticorps anti-CA IX dans le diagnostic et le traitement de troubles liés à une activité accrue de CA IX, en particulier, de tumeurs telles que le cancer colorectal, l'hypernéphrome (RCC), le cancer du col de l'utérus et d'autres cancers d'origine épithéliale.

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