Antibodies against ccr5 and uses thereof

Details Antibodies against ccr5 and uses thereof Antibodies against ccr5 and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) C07K 16/28 (2006.01) C12N 5/16 (2006.01) C12P 21/08 (2006.01) C07K 14/175 (2006.01)

Patent

CA 2603692

An antibody binding to human CCR5 comprising a variable heavy chain and a variable light chain, characterized in that the variable heavy chain comprises CDR sequences CDRl, CDR2 and CDR3 and CDRl being selected from the group consisting of SEQ ID NOs: 9, 10, 11, 12, CDR2 being selected from the group consisting of SEQ ID NOs: 13, 14, 15, CDR3 being selected from the group consisting of SEQ ID NOs: 16, 17, wherein said CDRs are selected independently of each other, or is a chimeric, humanized variant or a fragment of said antibody, has advantageous properties for the treatment of immunosuppressive diseases.

L'invention concerne un anticorps se liant au CCR5 humain, comprenant une chaîne lourde variable et une chaîne légère variable, se caractérisant en ce que la chaîne lourde variable comprend des séquences CDR, CDR1, CDR2 et CDR3, CDR1 étant sélectionnée dans le groupe constitué par SEQ ID NO: 9, 10, 11, 12, CDR2 étant sélectionnée dans le groupe constitué par SEQ ID NO: 13, 14, 15, CDR3 étant sélectionnée dans le groupe constitué par SEQ ID NO: 16, 17, lesdites CDR étant sélectionnées indépendamment les unes des autres, ou est un variant humanisé chimérique ou un fragment dudit anticorps. L'anticorps selon l'invention présente des propriétés avantageuses dans le traitement des maladies immunosuppressives.

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