Antibodies against e-selectin

Details Antibodies against e-selectin Antibodies against e-selectin

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2186455

This invention relates to whole antibodies of neutral isotype having specificity for E-selectin, process for their preparation (using vectors), pharmaceutical compositions containing them, and their use in therapy (e.g. for inflammatory disorders) and diagnosis. Said antibodies are variants of natural antibodies altered in the Fc region, especially in the CH2 domain, so that the interactions with antibodies Fc receptors and complement are absent or very low.

La présente invention concerne: des anticorps entiers à isotype neutre spécifiques de la sélectine E, à un procédé pour leur préparation (au moyen de vecteurs), à des compositions pharmaceutiques à base de ces anticorps et à leur utilisation à des fins thérapeutiques (par exemple contre les maladies inflammatoires) et diagnostiques. Ces anticorps sont des variants d'anticorps naturels modifiés dans la région F¿c?, notamment dans le domaine CH¿2?, pour que les intéractions avec les récepteurs F¿c? d'anticorps et avec leur complément soient inexistantes ou très faibles.

Affiliated with

Also associated with

Rating

Antibodies against e-selectin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibodies against e-selectin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies against e-selectin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1649200