Antibodies against erbb3 and uses thereof

Details Antibodies against erbb3 and uses thereof Antibodies against erbb3 and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) G01N 33/574 (2006.01) C07K 14/71 (2006.01)

Patent

CA 2678181

The present invention provides a novel class of monoclonal antibodies which bind ErbB3 receptor and inhibits various ErbB3 functions. For example, the antibodies described herein are capable of binding to ErbB3 and inhibiting EGF-like ligand mediated phosphorylation of the receptor.

La présente invention concerne une nouvelle classe d'anticorps monoclonaux qui se lient au récepteur ErbB3 et inhibe diverses fonctions de ErbB3. Par exemple, les anticorps décrits ici sont capables de se lier à ErbB3 et d'inhiber la phosphorylation du récepteur induite par un ligand de type EGF.

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