C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/36 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) C40B 40/10 (2006.01) C40B 50/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2535489
The present invention discloses inhibitory antibodies against Factor VIII with modified glycosylation, either by enzymatic deglycosylation or by site directed mutagenesis. Said antibodies with modified glycosylation have equal affinity for FVIII but show different inhibiting properties. The use of one or a mixture of said antibodies allow modulation of the inhibition of factor VIII to levels between 40 and 95%. The present invention further disclosed pharmaceutical compositions comprising inhibitory antibodies against Factor VIII with modified glycosylation, combinations of these antibodies and methods for treating haemostasis disorders using said antibodies and antibody mixtures.
L'invention concerne des anticorps inhibiteurs contre le facteur VIII présentant une modification de la glycosylation, soit par déglycosylation enzymatique, soit par mutagénèse ciblée. Ces anticorps possédant une glycosylation modifiée présentent une affinité égale pour FVIII, mais des propriétés d'inhibition différentes. L'utilisation d'un de ces anticorps ou d'un mélange desdits anticorps permet de moduler l'inhibition du facteur VIII à des niveaux situés entre 40 et 95 %. Elle concerne également des compositions pharmaceutiques comprenant des anticorps inhibiteurs du facteur VIII présentant une glycosylation modifiée, des combinaisons de ces anticorps et des méthodes servant à traiter des troubles hémostatiques au moyen desdits anticorps et desdits mélanges d'anticorps.
Jacquemin Marc
Saint-Remy Jean-Marie
D. Collen Research Foundation Vzw
Smart & Biggar
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