A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2321165
The Applicants have discovered novel chimeric and humanized anti-human CD40 antibodies which block the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating humoral immune responses against T cell-dependent antigens, collagen induced arthritis, and skin transplantation, and are also useful for their anti-inflammatory properties.
L'invention porte sur de nouveaux anticorps chimères et humanisés anti CD40 qui bloquent l'interaction entre le gp39 et le CD40 et s'avèrent efficaces: pour moduler la réponse immunitaire humorale contre les antigènes dépendants des cellules T, contre l'arthrite induite par le collagène, lors des transplantations de la peau, et en raison de leurs propriétés anti-inflammatoires.
Aruffo Alejandro A.
Bajorath Jurgen
Berry Karen K.
Harris Linda J.
Hollenbaugh Diane
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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