Antibodies against human il-21 receptor and uses therefor

Details Antibodies against human il-21 receptor and uses therefor Antibodies against human il-21 receptor and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01) C07K 16/28 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2518371

The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21 R). The antibodies can act as antagonists of IL-21 R activity, thereby modulating immune responses in general, and those mediated by IL-21 R in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.

La présente invention concerne des anticorps humains et certains de leurs fragments se liant à des antigènes et se liant de façon spécifique au récepteur humain de l'interleukine 21 (IL-21 R). Ces anticorps peuvent agir comme des antagonistes de l'activité de l'IL-21 R, modulant ainsi les réponses immunitaires en général, et plus particulièrement celles où intervient la médiation de l'IL-21 R. Les compositions et procédés de l'invention conviennent notamment au diagnostic, au traitement ou à la prévention de troubles inflammatoires, de maladies auto-immunes, d'allergies, du rejet de greffe, du cancer, et d'autres troubles du système immunitaire.

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