Antibodies against human il-22 and uses therefor

Details Antibodies against human il-22 and uses therefor Antibodies against human il-22 and uses therefor

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) C07K 14/54 (2006.01)

Patent

CA 2643226

The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those mediated by IL-22 in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, septic shock, infectious disorders, transplant rejection, cancer, and other immune system disorders.

La présente invention concerne des anticorps humains et des fragments de liaison antigénique de ces anticorps qui se lient spécifiquement à l'interleukine 22 (IL-22) humaine. Ces anticorps peuvent agir comme des antagonistes de l'activité de l'IL-22, modulant ainsi les réponses immunitaires en général et celles médiées par l'IL-22 en particulier. Les compositions et les procédés de l'invention peuvent être utilisés par exemple dans le diagnostic, le traitement ou la prévention de troubles inflammatoires, de maladies auto-immunes, d'allergies, du choc septique, de troubles infectieux, du rejet de greffe, du cancer et d'autres troubles du système immunitaire.

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