Antibodies against human interleukin-13 and uses therefor

Details Antibodies against human interleukin-13 and uses therefor Antibodies against human interleukin-13 and uses therefor

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2567129

This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL- 13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.

L'invention porte sur des anticorps, par exemple des anticorps humanisés, et leurs fragments de fixation aux antigènes se fixant à l'interleukine-13 (IL-13), et sur leur utilisation pour réguler les réponses immunitaires médiées par l'IL-13. Lesdits anticorps peuvent servir à diagnostiquer, prévenir et/ou traiter chez un sujet, par exemple un patient humain un ou plusieurs troubles associés à l'IL-13, par exemple: des troubles respiratoires tels que l'asthme; des troubles atopiques tels que la rhinite allergique; des états inflammatoires et/ou auto-immunes de la peau tels que la dermatite atopique; des affections des organes gastro-intestinaux tels que les affections abdominales inflammatoires; ainsi que des troubles fibrotiques ou cancéreux.

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