C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2708854
The present invention provides isolated anti-human NKG2D monoclonal antibodies useful for therapeutic applications in humans. Typically, the antibodies are fully human or humanized to minimize the risk for immune responses against the antibodies when administered to a patient. Preferred antibodies include human monoclonal antibodies MS and 21 F2. As described herein, other antigen-binding molecules such as, e.g., antigen-binding antibody fragments, antibody derivatives, and multi-specific molecules, can be designed or derived from such antibodies.
La présente invention fournit des anticorps monoclonaux humains anti-NKG2D isolés utiles pour des applications thérapeutiques chez les humains. D'une manière générale, les anticorps sont entièrement humains ou humanisés pour minimiser le risque de réponses immunitaires contre les anticorps lorsqu'ils sont administrés à un patient. Les anticorps préférés incluent les anticorps monoclonaux humains MS et 21 F2. Comme décrit dans la présente invention, d'autres molécules d'anticorps telles que, par exemple, les fragments d'anticorps de liaison à l'antigène, les dérivés d'anticorps et les molécules multispécifiques, peuvent être conçues à partir de ces anticorps ou dérivées de ceux-ci.
Lund Pedersen Inger
Svensson Anders
Ursoe Birgitte
Wagtmann Peter Andreas Nicolai Reumert
Dimock Stratton Llp
Novo Nordisk A/s
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