Antibodies against il-13 receptor alpha 1 and uses thereof

Details Antibodies against il-13 receptor alpha 1 and uses thereof Antibodies against il-13 receptor alpha 1 and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 11/06 (2006.01) A61P 37/08 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/20 (2006.01) C12N 15/63 (2006.01) C12N 15/79 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2592614

An antibody binding to IL-13R.alpha.l, inhibiting IL-13 bioactivity and comprising a variable heavy and a variable light chain, characterized in that the variable heavy chain amino acid sequence CDR3 of said antibody is selected from the group consisting of the heavy chain CDR3 sequences of SEQ ID NO: 1, 3, 5, 7 or 9 is useful in the treatment of asthma and allergic diseases.

La présente invention décrit un anticorps se liant au récepteur .alpha.1 de l'IL-13, inhibant la bio-activité de l'IL-13 et comprenant une chaîne lourde variable et une chaîne légère variable, caractérisé en ce que la séquence CDR3 d'acides aminés de la chaîne lourde variable dudit anticorps est choisie dans le groupe se composant des séquences CDR3 de la chaîne lourde telles que SEQ ID N°: 1, 3, 5, 7 ou 9 et est utile dans le traitement de l'asthme et de maladies allergiques.

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