C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 5/20 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2519113
An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IG-RI which is characterized in that said antibody is of human IgG1 isotype, and shows a ratio of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IGF-II to IGF-IR of 1:3 to 3:1, and induces celle death of 20% or more cells of a preparation of IGF-IR expressing cells after 24 hours at a concentration of said antibody of 100 nM by ADCC; has improved properties in antitumor therapy.
L'invention concerne un anticorps se liant à IGF-IR et inhibant la liaison de IGF-I et IGF-II avec IGF-IR, caractérisé en ce qu'il est de l'isotype IgG1, et en ce qu'il fait preuve d'un rapport entre l'inhibition de la liaison de IGF-I avec IGF-IR et l'inhibition de la liaison de IGF-II avec IGF-IR compris entre 1:3 et 3:1, et en ce qu'il induit la mort cellulaire d'au moins 20 % des cellules d'une préparation de cellules exprimant IGF-IR après 24 heures dans une concentration de cet anticorps de 100 nM par ADCC. Cet anticorps possède des propriétés améliorées pour la thérapie antitumorale.
Graus Yvo
Kopetzki Erhard
Kuenkele Klaus-Peter
Mundigl Olaf
Parren Paul
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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