Antibodies against insulin-like growth factor i receptor and...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 5/12 (2006.01)

Patent

CA 2672715

An antibody binding to IGF-IR and being glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is between 20% and 50%, has improved properties in antitumor therapy.

La présente invention concerne un anticorps se liant au récepteur IGF-IR et étant glycosylé avec une chaîne de sucres en Asn297. Ledit anticorps est caractérisé en ce que la quantité de fucose à l'intérieur de ladite chaîne de sucres est entre 20 % et 50 %, et présente des propriétés améliorées dans la thérapie antitumorale.

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