C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C07K 16/24 (2006.01) C12N 15/63 (2006.01) C07K 14/545 (2006.01)
Patent
CA 2590164
Antibodies directed to the antigen IL-1.beta. and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen IL-1.beta. are discussed. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are described.
L'invention concerne des anticorps dirigés contre l'antigène IL-1ß et les utilisations de ces anticorps et notamment des anticorps monoclonaux complètement humains dirigés contre l'antigène IL-1ß. L'invention concerne des séquences nucléotidiques codant pour des molécules d'immunoglobuline de chaînes lourdes et légères, et des séquences d'acides aminés comprenant ces molécules d'immunoglobuline de chaînes lourdes et légères, notamment des séquences correspondant aux séquences de chaînes lourdes et légères contiguës couvrant les régions de charpente et/ou les régions de détermination de la complémentarité (CDR), spécifiquement de FR1 à FR4 ou de CDR1 à CDR3. Des hybridomes ou d'autres lignées cellulaires exprimant ces molécules d'immunoglobuline et ces anticorps monoclonaux.
Faggioni Raffaella
Foord Orit
Green Larry
Klakamp Scott L.
Schneider Amy K.
Amgen Fremont Inc.
Smart & Biggar
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