C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 45/00 (2006.01)
Patent
CA 2634262
The present invention relates to antibodies and antigen-binding fragments that bind to interleukin-22 binding protein, in particular, human interleukin-22 binding protein (IL-22 BP), and are involved in regulating interleukin-22-associated biological responses. The invention also relates to methods of using the antibodies and antigen-binding fragments to treat disorders associated with interleukin-22. The antibodies disclosed herein are useful in diagnosing, preventing, or treating metabolic disorders including obesity, diabetes, hyperlipidemia and hyperinsulinemia etc.
La présente invention concerne des anticorps et des fragments de liaison à l'antigène qui lient à la protéine de liaison interleukine-22, en particulier, cette même protéine humaine (IL-22 BP) ; ils participent à l'activité régularisante des réponses biologiques associées à l'interleukine 22. L'invention a aussi trait à des procédés d'utilisation des anticorps et des fragments de liaison à l'antigène permettant de traiter les troubles associés à l'interleukine 22. Les anticorps présentés ici sont utiles dans le diagnostic, la prévention ou le traitement de troubles métaboliques y compris l'obésité, le diabète, l'hyperlipidémie, l'hyperinsulinémie, etc.
Chen Xu Wen
Huang Yu Liang
Huang Zhi Hua
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Dhy & Co. Ltd
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