C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2637775
This invention relates generally to the preparation of SFRP-4-binding agents and uses of the same. In particular the present invention relates to the preparation of anti-SFRP-4 antibodies and their use for SFRP-4 detection and modulation of SFRP-4-mediated function. The compositions and methods of the invention can be employed in diverse tissues to detect disorders manifested by altered SFRP-4 polypeptide expression as well as to affect therapeutic and prophylactic relief for such SFRP-4 polypeptide-associated disorders in a subject in need thereof.
La présente invention concerne de manière générale la préparation d'agents de liaison du SFRP-4 et leur utilisation. L'invention porte en particulier sur la préparation d'anticorps anti-SFRP-4 et de leur utilisation pour détecter le SFRP-4 et moduler les fonctions induites par le SFRP-4. Les compositions et les procédés de l'invention peuvent être utilisés dans divers tissus en vue de détecter des troubles manifestés par une modification de l'expression du polypeptide SFRP-4 et également de traiter et prévenir de tels troubles associés au polypeptide SFRP-4 chez un sujet nécessitant un tel traitement.
Hillenbrand Rainer
Vitaliti Alessandra
Zaar Annette
Fetherstonhaugh & Co.
Novartis Ag
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