C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2519528
The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
L'invention ici décrite concerne des anticorps dirigés contre l'antigène TIM-1 et les utilisations de ces anticorps. En particulier, l'invention concerne des anticorps monoclonaux entièrement humains dirigés contre l'antigène TIM-1. L'invention concerne aussi des séquences polynucléotidiques isolées codant, et des séquences d'acides aminés comprenant, des molécules d'immunoglobuline et à chaînes lourdes et légères, en particulier des séquence correspondant à des séquences de chaînes lourdes et légères contiguës couvrant les régions de cadre (FR) et/ou des régions de détermination de complémentarité (CDR) spécifiquement de FR1 à FR4 ou de CDR1 à CDR3. L'invention concerne aussi des hybridomes ou d'autres lignées cellulaires exprimant de telles molécules d'immunoglobuline et lesdits anticorps monoclonaux.
Bezabeh Binyam
Chen Francine
Foltz Ian
Jeffers Michael
Khramtsov Nikolia
Abgenix Inc.
Curagen Corporation
Ridout & Maybee Llp
LandOfFree
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