Antibodies against tenascin-c

Details Antibodies against tenascin-c Antibodies against tenascin-c

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2586661

Specific binding members against extracellular matrix protein tenascin-C, especially scFv antibody molecules against domain A1, domain C and domain D of tenascin-C. Anti-tenascin-C specific binding members conjugated with labels, cytotoxic molecules or cytokines. Use of anti-tenascin-C specific binding members in diagnosis and treatment, especially of cancer.

L'invention concerne des éléments de liaison spécifiques agissant comme anticorps vis-à-vis de la ténascine C des protéines de la matrice extracellulaire, en particulier des molécules d'anticorps scFv vis-à-vis du domaine A1, du domaine C et du domaine D de la ténascine C. On décrit en outre des éléments de liaison spécifiques anti-ténascine C conjugués à des étiquettes, des molécules cytotoxiques ou des cytokines. On décrit enfin l'utilisation d'éléments de liaison spécifiques anti-ténascine- C aux fins de diagnostic et de traitement, en particulier pour le cancer.

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