A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 16/28 (2006.01) C12P 1/04 (2006.01)
Patent
CA 2590671
Monoclonal antibodies that are specific for vascular endothelial growth factor receptor 1 (VEGFR-1). This invention also provides nucleotide sequences encoding and amino acid sequences comprising variable heavy and light chain immunoglobulin molecules, including sequences corresponding to the complementarity determining regions of CDR1, CDR2, and CDR3. The invention also provides methods for generation and expression of anti-VEGFR-1 antibodies and methods of treating angiogenic-related disorders and reducing tumor growth by administering anti~-VEGFR-1 antibodies.
L'invention concerne des anticorps monoclonaux spécifiques du récepteur 1 du facteur de croissance endothéliale vasculaire (VEGFR-1). Cette invention concerne également des séquences nucléotidiques codant pour des séquences d'acides aminés comprenant des molécules d'immunoglobuline à chaîne lourde et à chaîne légère, y compris des séquences correspondant aux régions complémentaires déterminantes CDR1, CDR2 et CDR3. L'invention concerne également des méthodes destinées à la production et à l'expression d'anticorps anti-VEGFR-1, ainsi que des méthodes destinées au traitement de troubles liés à l'angiogenèse et à la réduction de la croissance tumorale, consistant à administrer des anticorps anti-VEGFR-1.
Bohlen Peter
Hicklin Daniel J.
Wu Yan
Gowling Lafleur Henderson Llp
Imclone Llc
Imclone Systems Incorporated
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