C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01)
Patent
CA 2571404
The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV), and methods for preventing, treating or ameliorating symptoms associated with a flavivirus, particularly of West Nile Virus (WNV), infection utilizing said compositions. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with WNV infection, said methods comprising administering to a human subject an effective amount of one or more antibodies or fragments thereof that immunospecifically bind to a WNV antigen. The present invention also relates to detectable or diagnostic compositions comprising antibodies or fragments thereof that immunospecifically bind to a WNV antigen and methods for detecting or diagnosing WNV infection utilizing said compositions.
L'invention concerne des compositions qui contiennent des anticorps ou des fragments d'anticorps qui se lient immunospécifiquement à un ou plusieurs antigènes d'un flavivirus, en particulier le virus West Nile (WNV). L'invention concerne par ailleurs des procédés de prévention, de traitement ou d'atténuation des symptômes associés au flavivirus, en particulier l'infection par le virus West Nile (WNV), au moyen de ces compositions. Plus particulièrement, l'invention concerne des procédés de prévention, de traitement ou d'atténuation des symptômes associés à l'infection par WNV, et qui consistent à administrer à un sujet humain une dose efficace d'un ou de plusieurs anticorps ou fragments d'anticorps qui se lient immunospécifiquement à l'antigène WNV. De plus, l'invention concerne des compositions de dépistage ou de diagnostic qui contiennent des anticorps ou des fragments d'anticorps qui se lient immunospécifiquement à l'antigène WNV, ainsi que des procédés de dépistage ou de diagnostic de l'infection WNV au moyen de ces compositions.
Diamond Michael
Doane Christopher Michael
Oliphant Theodore
Smart & Biggar
Washington University
LandOfFree
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