Antibodies and epitopes specific to misfolded prion protein

Details Antibodies and epitopes specific to misfolded prion protein Antibodies and epitopes specific to misfolded prion protein

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 7/06 (2006.01) C07K 16/18 (2006.01) C12N 5/16 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2753621

The present invention relates to antibodies and immunogenic peptides specific to misfolded prion protein (PrP, e g, PrP Sc) and uses thereof. The immunogenic peptides comprise the amino acid sequence tyrosine-methionine-leucine (YML). The antibodies or peptides can be used for treating or preventing a disease or disorder associated with misfolded PrP, including cancer. In particular, a IgM monoclonal antibody designated "1A1" was generated using a peptide consisting of the sequence GGYMLGS (i e, SEQ ID NO 8), which corresponds to residues 126-132 of human PrP 1A1 recognizes misfolded PrP, but not normal PrP.

Anticorps et peptides immunogènes spécifiques d'une protéine prion « tordue » (PrP, e g, PrPSc) et leurs utilisations. Les peptides immunogènes comprennent la séquence d'acides aminés tyrosine-méthionine-leucine (YML). Les anticorps ou les peptides peuvent être utilisés pour le traitement ou la prévention d'une maladie ou d'un trouble associé à une PrP « tordue », y compris le cancer. En particulier, un anticorps monoclonal IgM appelé « 1A1 » a été obtenu au moyen d'un peptide constitué par la séquence GGYMLGS (i e, SEQ ID NO 8), laquelle correspondant à des résidus de 126-132 d'une PrP 1A1 avérée PrP « tordue », et non comme une PrP normale.

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