Antibodies and fc fusion proteins with altered immunogenicity

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/00 (2006.01)

Patent

CA 2595169

Variant antibodies and Fc fusion proteins with reduced immunogenicity are described. In particular, the variants of antibodies and Fc fusion proteins have reduced ability to bind one or more human class Il MHC molecules are described.

L'invention porte sur des variantes d'anticorps et des protéines de fusion Fc à immunogénicité réduite et en particulier sur de telles variantes présentant une capacité réduite de fixation à une ou plusieurs molécules MHC humaines de classe II.

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