Antibodies and immunotoxins that target human glycoprotein nmb

Details Antibodies and immunotoxins that target human glycoprotein nmb Antibodies and immunotoxins that target human glycoprotein nmb

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C12N 15/13 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2627890

The invention provides high affinity antibodies suitable for forming immunotoxins that inhibit the growth of cells expressing human glycoprotein NMB, including glioblastoma multiform cells, anaplastic astrocytoma cells, anaplastic oligodendroglioma cells, oligodendroglioma cells, and melanoma cells.

L'invention porte sur des anticorps à haute affinité aptes à former des immunotoxines qui inhibent la croissance de cellules exprimant la glycoprotéine humaine NMB, y compris les cellules de glioblastomes multiformes, les cellules d'astrocytomes anaplastiques, les cellules d'oligodendrogliomes et les cellules de mélanomes.

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