Antibodies and methods for making and using them

Details Antibodies and methods for making and using them Antibodies and methods for making and using them

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2673725

The invention provides antibodies, including chimeric human antibodies, recombinant antibodies, synthetic antibodies, and the nucleic acids encoding them, and methods for making and using these immunoglobulins. The invention provides recombinant and synthetic polypeptide and nucleic acid embodiments of these polypeptides and/or antibodies. The invention also provides polypeptides comprising, or consisting of, consensus human framework regions, or "Independently Consensused Frameworks (ICFs)", nucleic acids encoding them, and libraries and kits comprising these ICFs and/or antibodies of the invention, individually and in combinatorial libraries and combinations.

L'invention propose des anticorps, y compris des anticorps chimères humains, des anticorps recombinés, des anticorps de synthèse et les acides nucléiques qui les codent, et des procédés de fabrication et d'utilisation de ces immunoglobulines. L'invention propose des modes de réalisation de polypeptide de synthèse et recombinés et d'acide nucléique de ces polypeptides et/ou anticorps. L'invention propose également des polypeptides comportant des régions structurales humaines consensus ou des <= structures indépendamment consensuelles (ICF) >=, ou constitués de celles-ci, les acides nucléiques qui les codent et les pharmacothèques et les kits qui comprennent ces ICF et/ou les anticorps de l'invention, individuellement et dans des pharmacothèques et des combinaisons.

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