Antibodies and methods of use thereof

Details Antibodies and methods of use thereof Antibodies and methods of use thereof

C - Chemistry, Metallurgy

07

K

C07K 16/40 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C12N 9/50 (2006.01) C12N 15/13 (2006.01) C40B 40/08 (2006.01)

Patent

CA 2761310

The disclosure relates to protease-binding agent specific for a protease. The agent may be an antibody capable of specifically binding and inhibiting a protease, such as a P1-Arg-specific protease. The disclosure also provides methods of producing, and compositions comprising the subject agent. Methods and kits related to the protease-binding agent find use in protection against, detection, diagnosing, treating cancer and infections due to pathogens containing active proteases.

L'invention porte sur un agent de liaison à une protéase, spécifique pour une protéase. L'agent peut être un anticorps capable de se lier spécifiquement et d'inhiber une protéase, telle qu'une protéase spécifique de P1-Arg. L'invention porte également sur des procédés de production et sur des compositions comprenant le présent agent. L'invention porte sur des procédés et des trousses apparentés à l'agent de liaison à une protéase qui se révèlent utiles pour la protection contre, la détection, le diagnostic, le traitement d'un cancer et d'infections dues à des pathogènes contenant des protéases actives.

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