Antibodies and molecules derived therefrom that bind to...

Details Antibodies and molecules derived therefrom that bind to... Antibodies and molecules derived therefrom that bind to...

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01)

Patent

CA 2563735

Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.

L'invention concerne des anticorps et des molécules dérivées de ceux-ci se liant à la protéine STEAP-1 et des variants de ceux-ci, la STEAP-1 possédant une expression spécifique des tissus dans des tissus adultes normaux et étant exprimée de manière aberrante dans les cancers présentés dans la Table I. Par conséquent, la STEAP-1 met en place une cible diagnostique, pronostique, prophylactique et/ou thérapeutique pour le cancer. Le gène de la STEAP-1 ou un fragment de celui-ci ou la protéine codée de celui-ci ou des variants de celui-ci ou un fragment de celui-ci peut être utilisé pour provoquer une réponse immune humorale ou cellulaire; des anticorps ou des lymphocytes T réactifs avec la STEAP-1 pouvant être utilisés dans une immunisation active ou passive.

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