Antibodies and peptide antigens for producing antibodies...

Details Antibodies and peptide antigens for producing antibodies... Antibodies and peptide antigens for producing antibodies...

C - Chemistry, Metallurgy

07

K

C07K 16/26 (2006.01) G01N 33/533 (2006.01) G01N 33/78 (2006.01)

Patent

CA 2589471

Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1- 15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the same. Such antigens, antibodies and methods producing the same according to the present invention are useful in determining bioactive intact PTH levels in serum, plasma, and/or cell culture media. Such antibodies further possess a high degree of species cross- reactivity, but substantially mitigated cross-reactivity to non-whole PTH peptide fragments and little to no recognition of the first amino acid residue of PTH.

L'invention porte sur des antigènes peptidiques correspondant aux résidus d'acides aminés 2-12, 1-12, 2-15 et 1-15 de l'hormone parathyroïde (PTH), sur des anticorps ayant une affinité aux antigènes peptidiques et sur des procédés de production de ces antigènes. Ces antigènes, ces anticorps et leurs procédés de production sont utiles pour déterminer les taux de l'hormone parathyroïde intacte bioactive dans le sérum, le plasma et/ou un milieu de culture cellulaire. Ces anticorps possèdent également un haut degré d'activité hétérospécifique, et une activité hétérospécifique sensiblement mitigée par rapport aux fragments peptidiques non entiers de la PTH et un faible degré par rapport à la non reconnaissance du premier résidu d'acides aminés de la PTH.

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