Antibodies and related molecules that bind to 161p2f10b...

Details Antibodies and related molecules that bind to 161p2f10b... Antibodies and related molecules that bind to 161p2f10b...

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2603093

Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.

L'invention porte sur des anticorps et sur des molécules dérivées de ces anticorps qui se fixent à la protéine 161P2F10B et à des variants de celle-ci. La protéine 161P2F10B présente une expression spécifique d'un tissu dans un tissu d'adulte normal et est exprimée de manière aberrante dans les cancers dont la liste est dans le tableau I. En conséquence, la protéine 161P2F10B est une cible diagnostique, pronostique, prophylactique et/ou thérapeutique du cancer. Le gène 161P2F10B ou le fragment de ce gène, ou sa protéine codée, ou des variants de celle-ci, ou un fragment de celle-ci, peut être utilisé pour éliciter une réponse immune humorale ou cellulaire. Des anticorps ou des lymphocytes T réagissant à 161P2F10B peuvent être utilisés dans l'immunisation active ou passive.

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