Antibodies and related molecules that bind to 24p4c12 proteins

Details Antibodies and related molecules that bind to 24p4c12 proteins Antibodies and related molecules that bind to 24p4c12 proteins

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) C12N 15/113 (2010.01) A01K 67/027 (2006.01) A61K 31/713 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A01K 67/00 (2006.01)

Patent

CA 2698287

Antibodies and molecules derived therefrom that bind to 24P4Cl2 protein and variants thereof, are described wherein 24P4Cl2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4Cl2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4Cl2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4Cl2 can be used in active or passive immunization.

La présente invention concerne des anticorps et des molécules qui en sont dérivées qui se lient à la protéine 24P4C12 et à ses variantes, la 24P4C12 présentant une expression spécifique des tissus dans un tissu d'adulte normal et étant exprimée de façon aberrante dans les cancers listés dans le tableau I. Par conséquent, 24P4C12 fournit une cible diagnostique, pronostique, prophylactique et/ou thérapeutique pour le cancer. Le gène de 24P4C12 ou l'un de ses fragments, ou bien sa protéine codée, ou des variantes de celle-ci, ou un fragment de celle-ci, peuvent être utilisés pour induire une réponse immunitaire humorale ou cellulaire; des anticorps ou des lymphocytes T réactifs avec 24P4C12 peuvent être utilisés dans une immunisation active ou passive.

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