Antibodies and related molecules that bind to psca proteins

Details Antibodies and related molecules that bind to psca proteins Antibodies and related molecules that bind to psca proteins

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2567449

Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.

L'invention concerne des anticorps et des molEcules dErivEes de ces anticorps, qui se lient A une nouvelle protEine de PSCA, et les variantes de celle-ci, dans lesquels le PSCA prEsente une expression spEcifique des tissus dans un tissu adulte normal, et est exprimE de faÇon anormale dans les cancers EnumErEs dans le tableau I. Par consEquent, le PSCA fournit une source de diagnostic, de pronostic, de prophylaxie et/ou de thErapie pour le cancer. Le gEne de PSCA ou un fragment de celui-ci, ou sa protEine codEe, ou des variantes de celle-ci, ou un fragment de celle-ci, peut Etre utilisE pour provoquer une rEponse immunitaire humorale ou cellulaire; les anticorps ou les lymphocytes T rEactifs avec le PSCA peuvent Etre utilisEs dans le cadre d'une immunisation active ou passive.

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