C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01) C07K 16/40 (2006.01) C12N 5/18 (2006.01) C12N 9/04 (2006.01) C12N 15/53 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2620351
The present invention concerns an antibody which specifically binds to an abnormal superoxide dismutase 1 (SOD1), and which neutralizes its pathologic effect when administered to an animal such as a human. The antibody of the invention is a monoclonal antibody produced by hybridoma cell lines deposited with the International Depositary Authority of Canada on August 29th, 2006 under accession numbers ADI-290806-01 , ADI-290806-02 and ADI-290806-03. The present invention also concerns the use of the antibody of the invention in the treatment, prevention and diagnosis of neurodegenerative diseases such as Amyotrophic lateral sclerosis, Parkinson and Alzheimer in an animal such as a human.
La présente invention concerne un anticorps qui se lie spécifiquement à une superoxyde dismutase 1 (SOD1) anormale, et qui en neutralise l'effet pathologique lors d'une administration à un animal tel qu'un être humain. L'anticorps de l'invention est un anticorps monoclonal produit au moyen de lignées cellulaires d'hybridomes déposées par l'intermédiaire de l'Autorité de dépôt internationale du Canada le 29 août 2006 sous les numéros d'accès ADI-290806-01, ADI-290806-02 et ADI-290806-03. La présente invention concerne également l'utilisation de l'anticorps de l'invention dans le traitement, la prévention et le diagnostic de maladies neurodégénératives telles que la sclérose latérale amyotrophique, la maladie de Parkinson et la maladie d'Alzheimer chez un animal tel qu'un être humain.
Julien Jean-Pierre
Urushitani Makoto
Robic
Universite Laval
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