Antibodies and uses thereof

Details Antibodies and uses thereof Antibodies and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2491363

The present invention provides antibodies or fragments thereof that bind to cancer cells and are important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic, prognostic or staging methods and compositions using such antibodies or fragments thereof are also provided. The methods and compositions according to the present invention can be used in diagnosis of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, autoimmune disease, and inflammatory disease.

La présente invention a trait à des anticorps ou des fragments de ceux-ci de liaison aux cellules cancéreuses et jouant un rôle important dans des phénomènes physiologiques, tels que l'enroulement des cellules et la métastase. L'invention a également trait à des procédés thérapeutiques et diagnostiques, de pronostic ou de stadification et des compositions utilisant de tels anticorps ou fragments. Les procédés et compositions de la présente invention peuvent être utilisés dans le diagnostic et le traitement de maladies telles que le cancer, y compris la croissance tumorale et la métastase, la leucémie, les maladies auto-immunes, et les maladies inflammatoires.

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