Antibodies and uses thereof

Details Antibodies and uses thereof Antibodies and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/26 (2006.01) C07K 16/28 (2006.01) C07K 16/36 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C40B 40/02 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2536644

The present invention provides antibodies or fragments thereof that bind to cancer cells and is important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic methods and compositions using such antibody fragments thereof are also provided. The methods and compositions according to the present invention can be used in targeting therapeutic agents and in diagnosis, prognosis, and staging of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, auto-immune disease, and inflammatory disease. Also provided is a library of immunoglobulin binding domains having a diverse antigen-binding domain for complementary binding, wherein the library has diversity only in heavy chain CDR3.

L'invention concerne des anticorps ou des fragments de ceux-ci se liant à des cellules cancéreuses et jouant un rôle important dans les phénomènes physiologiques, tels que le roulement de cellules et la métastase. L'invention concerne également des procédés thérapeutiques et diagnostiques, ainsi que des compositions utilisant de tels fragments d'anticorps. Les procédés et compositions selon l'invention peuvent être utilisés dans le ciblage d'agents thérapeutiques et dans le diagnostic, le pronostic et l'évaluation du stade de maladies et la thérapie destinée à celles-ci, telles que le cancer, notamment la croissance tumorale et la métastase, la leucémie, une maladie auto-immune et une maladie inflammatoire. L'invention concerne enfin une bibliothèque de domaines de liaison à l'immunoglobuline comprenant un domaine de liaison aux antigènes différent destiné à une liaison complémentaire, la bibliothèque présentant une diversité uniquement dans une chaîne lourde CDR3.

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