Antibodies as a cancer diagnostic

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/16 (2006.01) C07K 16/32 (2006.01) C07K 16/40 (2006.01) C12P 21/08 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2382655

Method and kits are provided for the detection and diagnosis of metastatic disease. More particularly, the methods and kits employ compounds that can detect EphA2, a specific epithelial cell tyrosine kinase that is overexpressed in metastatic tumor cells. In one embodiment the compound is an antibody capable of binding to an epitope of EphA2.

La présente invention concerne un procédé et des kits destinés à la détection et au diagnostic de maladie métastatique. Plus particulièrement, ces procédés et ces kits utilisent des composés pouvant détecter EphA2, une tyrosine-kinase de cellule épithéliale spécifique surexprimée dans des cellules tumorales métastatiques. Dans un des modes de réalisation, ce composé est un anticorps capable de se lier à un épitope de EphA2.

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