Antibodies binding a non naturally occurring enantiomer...

Details Antibodies binding a non naturally occurring enantiomer... Antibodies binding a non naturally occurring enantiomer...

C - Chemistry, Metallurgy

07

K

C07K 16/44 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01)

Patent

CA 2389386

An antibody that has affinity for a non-naturally-occurring enantiomer (NNOE) of a chiral molecule whose naturally-occurring enantiomer (NOE) is endogenous, and that has no affinity for the NOE, can be used for targeting, in therapy or diagnostic procedures. The antibody may be conjugated to a therapeutic or diagnostic agent, e.g. a cytotoxic agent.

La présente invention concerne un anticorps, qui présente une affinité pour un énantiomère non naturel (NNOE) d'une molécule chirale dont l'énantiomère naturel (NOE) est endogène, et qui ne présente aucune affinité pour le NOE. Cet anticorps peut être utilisé pour le ciblage, dans des processus thérapeutiques ou diagnostiques. Cet anticorps peut être associé à un agent thérapeutique ou diagnostique, tel qu'un agent cytotoxique.

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